Published on: 29 September 2026
Profhilo is an injectable skin bio-remodeller containing 64mg of pure, thermally bound hyaluronic acid formulated without synthetic chemical cross-linkers. Unlike conventional dermal fillers designed to build localised facial volume, Profhilo diffuses smoothly across tissue layers using 5 strategic Bio Aesthetic Points (BAP) per side of the face to support collagen and elastin synthesis. The standard protocol involves 2 sessions spaced 4 weeks apart, providing deep hydration and progressive skin-firming effects lasting 6 to 9 months.
As skin matures, natural reserves of hyaluronic acid, collagen, and elastin gradually decline, contributing to mild skin laxity and uneven texture. Profhilo belongs to the category of skin bio-remodelling. Unlike treatments that alter your facial contours or relax your muscles, this works beneath the surface to deliver deep hydration and encourage natural skin cell renewal.
What Is Profhilo?
Profhilo is an injectable aesthetic treatment designed to target mild tissue laxity and improve overall skin quality. Unlike standard hyaluronic acid preparations focused primarily on immediate surface hydration, Profhilo works within deeper skin layers to encourage ongoing cellular activity.
High vs Low Molecular Weight Hyaluronic Acid (NAHYCO Technology)
This treatment utilises a high-concentration hyaluronic acid formulation containing 64mg per 2ml syringe. Instead of using synthetic chemical cross-linking agents (such as BDDE), it is engineered using a specialised thermal process to combine two different molecular weights of hyaluronic acid:- Low Molecular Weight (32mg): Intended to provide immediate hydration to the skin.
- High Molecular Weight (32mg): Helps form a supportive matrix beneath the skin that gradually releases moisture over approximately 28 days.
Is Profhilo a Dermal Filler? Clearing Up the Confusion
No, Profhilo is not a dermal filler. Dermal fillers use cross-linked HA gels to remain localised for targeted volume restoration, lip plumping, or jawline contouring.
This features high flowability and diffuses naturally across tissue planes rather than remaining in a single deposit. It is not intended to change facial structure, create volumetric fullness, or reshape feature contours. If structural contouring or jawline sharpening is your primary goal, explore our comprehensive guide to non-surgical V-shape face treatments in Singapore.
How Does Profhilo Work? The Biological Process Under the Skin
- Strategic Injection (BAP Technique): The procedure deposits 0.2ml across 5 anatomical points per side of the lower face into the subcutaneous layer where tissue diffusion is optimal.
- Intradermal Hydration: Low molecular weight (LMW) hyaluronic acid binds water molecules rapidly, increasing moisture levels within the dermis to soften surface dehydration lines.
- Tissue Diffusion: Over 24 to 48 hours, the fluid formula spreads smoothly within a 2cm radius from each placement point, integrating into the extracellular matrix without clumping.
- Fibroblast Support: The high molecular weight (HMW) HA remains active within the tissue for around 28 days, acting as a temporary matrix that supports dermal fibroblast activity and multi-collagen synthesis. Research published on PubMed Central demonstrates how hybrid hyaluronic acid complexes help restore extracellular matrix density, leading to progressive improvements in skin hydration, firmness, and elasticity.
- Elastin & Structural Renewal: The hybrid complex encourages elastin synthesis alongside collagen integration. As new collagen and elastin fibres integrate into the dermis, the skin undergoes bio-remodelling. This process results in improved elasticity, firmer density, and structural rejuvenation.
Profhilo vs Other Aesthetic Treatments: Choosing the Right Modality
| Feature / Goal | Profhilo | Rejuran Healer | Traditional Dermal Fillers | Standard Skin Boosters |
|---|---|---|---|---|
|
Primary Ingredient |
High & Low Pure HA (64mg) |
Salmon DNA Polynucleotides (PN) |
Cross-linked HA Gel |
Non-cross-linked HA |
|
Primary Function |
Bio-remodelling & skin tightening |
Cellular repair & acne scar healing |
Structural volumising & projection |
Superficial hydration & glow |
|
Injection Points |
5 points per side (Face) |
Hundreds of micro-injections |
Target areas (e.g., cheeks, chin) |
Micro-droplets across face |
|
Facial Volumising |
Minimal |
None |
High (Restores lost volume) |
3–6 months for subtle changes |
|
Downtime |
24–48 hours (Small bumps) |
2–3 days (Micro-papules) |
Minimal (Mild swelling/bruising) |
1–2 days |
- Profhilo vs PN Treatments: Profhilo uses pure HA to hydrate and support structural bio-remodelling across the lower face and neck. In contrast, PN treatments focus on skin barrier repair, calming inflammation, and improving scar-prone skin texture.
- Profhilo vs Dermal Fillers: Dermal fillers use cross-linked HA to act as volumetric cushions. Profhilo has zero structural lifting capacity; it diffuses beneath the skin to support the overlying tissue matrix without changing underlying volume.
- Profhilo vs Standard Skin Boosters: Standard skin boosters provide superficial moisture via multiple placement points across the face. Profhilo requires fewer injection points, remains active longer in tissue, and actively supports collagen and elastin synthesis.
Treatment Protocol and What to Expect During Your Session
Candidate Suitability
Profhilo is suitable for men and women experiencing early-to-moderate signs of skin ageing.
- Ideal Candidates: Individuals aged 30 and above showing mild skin laxity, fine lines, dullness, or dehydration on the face, neck, or hands.
- Is 60 Too Old for Profhilo? Not at all. Mature skin benefits greatly from the hydration boost and tissue renewal. However, if severe skin sagging or deep structural volume loss is present, This works best when combined with energy-based tightening devices or dermal fillers.
- Contraindications: This treatment should be avoided by pregnant or breastfeeding mothers, individuals with active skin infections or cold sores near injection sites, or those with known hypersensitivity to hyaluronic acid.
Recommended Session Spacing for Optimal Results
For complete bio-remodelling, the standard protocol consists of:
- Initial Cycle: 2 sessions spaced 4 weeks apart.
- Maintenance Cycle: 1 single session every 6 to 9 months to maintain collagen production and hydration levels.
Essential Pre-Treatment and Post-Care Guidelines
- Before Treatment: Avoid blood-thinning supplements (such as Vitamin E, Fish Oil, or Ginkgo) and alcohol for 3 to 5 days prior to minimise bruising risks.
- After Treatment: Avoid rubbing injection sites for 12 hours. Refrain from strenuous exercise, saunas, and steam rooms for 48 hours. Avoid swimming or applying heavy makeup on the day of treatment.
Frequently Asked Questions
Does Profhilo change your face shape or cause a puffy appearance?
No. Because the formulation contains no synthetic chemical cross-linking agents, it does not hold a rigid shape or create structural volume. Instead, the liquid formula diffuses smoothly across tissue layers to improve overall skin hydration and quality without altering your natural facial features or proportions.
Can Profhilo be combined with Botox or energy devices (such as HIFU or RF skin tightening)?
Yes, multi-modality combination protocols are commonly performed in aesthetic practice. Each treatment targets a different tissue layer: energy-based devices focus on deeper structural layers (including the SMAS), botulinum toxin relaxes dynamic muscle movement, and bio-remodelling injections address the dermal skin layer. Energy devices are typically performed first, followed by bio-remodelling injections approximately 2 weeks later to allow targeted tissues to recover.
Is the 5-point injection technique uncomfortable?
Discomfort is generally minimal. The procedure uses a limited number of injection points (typically 5 per side), and a topical numbing cream is applied beforehand. Most individuals report experiencing only a brief, mild pinching or stinging sensation as the solution is placed beneath the skin.
Why Choose Dr Shane for Treatment in Singapore?
If you are ready to move past the uncertainty of retail wellness trends and explore evidence-based clinical treatments tailored to your face, we welcome you to contact our team.
At Dr Shane’s clinic, we believe remarkable results begin with three fundamentals: medical precision, honest advice, and customised care.
While many clinics focus on selling treatments, we prioritise:
- In-depth 1-1 skin health consultations (at least 30 mins)
- HSA/FDA-compliant protocols using approved devices with documented safety profiles
- Personalised energy settings adjusted for your unique skin thickness and concerns
What makes our approach different?
✔ Doctor-Led Consultations
Every treatment plan begins with a medical evaluation of your skin’s needs – not a sales conversation.
✔ Safety-First Philosophy
We use only HSA-approved devices and disclose all potential risks transparently.
✔ No Pressure, Just Professional Advice
You’ll leave your consultation either:
- Confident this treatment is right for you, or
- Aware of better alternatives for your goals
✔ Natural-Looking Results
Our treatment plans prioritise gradual, authentic improvement over dramatic but short-lived changes.
✔ Continued Aftercare
Post-treatment guidance to help maintain and optimise your results
The First Step is Always a Conversation
Many patients discover during consultation that their skin concerns actually require:
→ A different treatment approach
→ Combination therapies
→ Or simply more time before considering procedures
Book a skin health assessment to get professional insights before deciding on any treatment.
Let us help you find what’s right for your skin—not just what’s trending.
Secure your skin health consultation slot with Dr Shane today
Great skin starts with the right diagnosis.